Unless you have problems racking the slide of a full size 9mm, that is what I would recommend for home defense and range use. Besides having a longer barrel (for higher velocity), it is easier to handle in general (easier to manage the recoil, easier to grip) than the small subcompact pistols.
I have the 9 EZ, and like it a lot as an EDC, but I also have a full-size 9mm M&P 2.0 for home defense.
I bought the EZ for my carry pistol since my wife has arthritic hands and could not rack the full-size pistol. IOW, I wanted one she could actually use if need be. She can rack the 9 EZ just fine, and it is a good size for EDC.
She insisted on the thumb safety, BTW, and it causes no problems for me. It is a little stiff, but other than that, no issues with it.
If you bought the version with the thumb safety and don't want it, just leave it in the "fire" position all the time and it functionally disappears.
I bought the 9 EZ (rather than the 380) so I wouldn't have to stock different ammo.